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The monoclonal UCHT1 clone recognizes CD3? antigen, a 20KDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The CD3 complex contains a CD3? chain, a CD3? chain, and two CD3? chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ?-chain (zeta-chain) to generate an activation signal in T lymphocytes. CD3? is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays central roles in TCR signaling, T lymphocyte activation, and antigen recognition. Crosslinking of the TCR via plate bound UCHT1 monoclonal is widely used to study the activation T cell response in vitro.
iFluor™ fluorophores are optimized for strong fluorescence, high photostability and pH independence on proteins. They are avaialble to span the full UV-visible-IR spectrum. iFluor™647 is a great alternative to Alexa Fluor? 647, eFluor? 660. Do you need an antibody for an antigen you don't see on our website? Do you need a different conjugation than what we have listed? We have a wide selection of antigens with a variety of conjugations available. Please reach out to us at [email protected].